Antigenotoxic effects of Mandevilla velutina (Gentianales, Apocynaceae) crude extract on cyclophosphamide-induced micronuclei in Swiss mice and urethane-induced somatic mutation and recombination in Drosophila melanogaster

Antigenotoxic effects of Mandevilla velutina (Gentianales, Apocynaceae) crude extract on cyclophosphamide-induced micronuclei in Swiss mice and urethane-induced somatic mutation and recombination in Drosophila melanogaster

A Mandevilla velutina crude extract was investigated using the mouse micronucleus test (MNT) and the Drosophila melanogaster somatic mutation and recombination test (SMART) using standard (ST) and high bioactivation (HB) crosses. The MNT used 10 mg, 20 mg or 40 mg per 100 g of body weight (bw) of ex...

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Bibliographic Details
Main Authors: Regildo Márcio Gonçalves da Silva, Neila Coelho de Sousa, Ulrich Graf, Mário Antônio Spanó
Format: Article
Language:English
Published: Sociedade Brasileira de Genética 2008-01-01
Series:Genetics and Molecular Biology
Subjects:
antigenotoxicity
genotoxicity tests
micronucleus assay
SMART
wing spot test
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400023

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1415-47572008000400023

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