Histidine Enhances the Anticancer Effect of Gemcitabine against Pancreatic Cancer via Disruption of Amino Acid Homeostasis and Oxidant—Antioxidant Balance

Histidine Enhances the Anticancer Effect of Gemcitabine against Pancreatic Cancer via Disruption of Amino Acid Homeostasis and Oxidant—Antioxidant Balance

Due to the severe toxicity posed by chemotherapeutic drugs, adjuvant nutritional intervention has gained increased attention in the treatment of pancreatic cancer (PC). Amino acid (AA) metabolism is aberrantly regulated in PC and circulating histidine (His) levels are low in PC patients. We hypothes...

Full description

Bibliographic Details
Main Authors: Narendra Kumar, Satyanarayana Rachagani, Gopalakrishnan Natarajan, Alexandra Crook, Thiyagarajan Gopal, Vinothkumar Rajamanickam, Jyoti B. Kaushal, Sirpu N. Nagabhishek, Robert Powers, Surinder K. Batra, Viswanathan Saraswathi
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Cancers
Subjects:
pancreatic cancer
histidine
gemcitabine
glutathione
hydrogen peroxide
metabolomics
Online Access:https://www.mdpi.com/2072-6694/15/9/2593

Internet

https://www.mdpi.com/2072-6694/15/9/2593

Similar Items