Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

Mapping immune variation and var gene switching in naive hosts infected with Plasmodium falciparum

Falciparum malaria is clinically heterogeneous and the relative contribution of parasite and host in shaping disease severity remains unclear. We explored the interaction between inflammation and parasite variant surface antigen (VSA) expression, asking whether this relationship underpins the variat...

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Bibliographic Details
Main Authors: Kathryn Milne, Alasdair Ivens, Adam J Reid, Magda E Lotkowska, Aine O'Toole, Geetha Sankaranarayanan, Diana Munoz Sandoval, Wiebke Nahrendorf, Clement Regnault, Nick J Edwards, Sarah E Silk, Ruth O Payne, Angela M Minassian, Navin Venkatraman, Mandy J Sanders, Adrian VS Hill, Michael Barrett, Matthew Berriman, Simon J Draper, J Alexandra Rowe, Philip J Spence
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2021-03-01
Series:eLife
Subjects:
falciparum malaria
human immune variation
inflammation
var gene switching
metabolomics
systems immunology
Online Access:https://elifesciences.org/articles/62800

Internet

https://elifesciences.org/articles/62800

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