Synergising single-cell resolution and 4sU labelling boosts inference of transcriptional bursting

Synergising single-cell resolution and 4sU labelling boosts inference of transcriptional bursting

Abstract Despite the recent rise of RNA-seq datasets combining single-cell (sc) resolution with 4-thiouridine (4sU) labelling, analytical methods exploiting their power to dissect transcriptional bursting are lacking. Here, we present a mathematical model and Bayesian inference implementation to fac...

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Bibliographic Details
Main Authors: David M. Edwards, Philip Davies, Daniel Hebenstreit
Format: Article
Language:English
Published: BMC 2023-06-01
Series:Genome Biology
Subjects:
Transcription
Bursting
Dynamics
Inference
Time-resolved
4sU
Online Access:https://doi.org/10.1186/s13059-023-02977-y

Internet

https://doi.org/10.1186/s13059-023-02977-y

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