Maternal High Fat Diet Programs Male Mice Offspring Hyperphagia and Obesity: Mechanism of Increased Appetite Neurons via Altered Neurogenic Factors and Nutrient Sensor AMPK

Maternal High Fat Diet Programs Male Mice Offspring Hyperphagia and Obesity: Mechanism of Increased Appetite Neurons via Altered Neurogenic Factors and Nutrient Sensor AMPK

Maternal high-fat (HF) is associated with offspring hyperphagia and obesity. We hypothesized that maternal HF alters fetal neuroprogenitor cell (NPC) and hypothalamic arcuate nucleus (ARC) development with preferential differentiation of neurons towards orexigenic (NPY/AgRP) versus anorexigenic (POM...

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Bibliographic Details
Main Authors: Mina Desai, Monica G. Ferrini, Guang Han, Kavita Narwani, Michael G. Ross
Format: Article
Language:English
Published: MDPI AG 2020-10-01
Series:Nutrients
Subjects:
developmental programming
neuropeptides
hypothalamic arcuate nucleus
neuroprogenitor cells
AMPK activator
Online Access:https://www.mdpi.com/2072-6643/12/11/3326

Internet

https://www.mdpi.com/2072-6643/12/11/3326

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