Integration of metabolites from meta-analysis with transcriptome reveals enhanced SPHK1 in PDAC with a background of pancreatitis

Integration of metabolites from meta-analysis with transcriptome reveals enhanced SPHK1 in PDAC with a background of pancreatitis

Abstract Background Pathophysiology of transformation of inflammatory lesions in chronic pancreatitis (CP) to pancreatic ductal adenocarcinoma (PDAC) is not clear. Methods We conducted a systematic review, meta-analysis of circulating metabolites, integrated this data with transcriptome analysis of...

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Bibliographic Details
Main Authors: Vijayasarathy Ketavarapu, Vishnubhotla Ravikanth, Mitnala Sasikala, G. V. Rao, Ch. Venkataramana Devi, Prabhakar Sripadi, Murali Satyanarayana Bethu, Ramars Amanchy, H. V. V. Murthy, Stephen J. Pandol, D. Nageshwar Reddy
Format: Article
Language:English
Published: BMC 2022-07-01
Series:BMC Cancer
Subjects:
Chronic pancreatitis
Pancreatic ductal adenocarcinoma
PDAC with background of CP
SPHK1
Transcriptomics
Metabolomic biomarkers
Online Access:https://doi.org/10.1186/s12885-022-09816-6

Internet

https://doi.org/10.1186/s12885-022-09816-6

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