Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation

Live-cell single-molecule dynamics of PcG proteins imposed by the DIPG H3.3K27M mutation

Diffuse intrinsic pontine gliomas exhibit a characteristic mutation of lysine 27 to methionine (K27M) in genes encoding histone H3.3. Here the authors show that the H3.3K27M mutation imposes a specific pattern of H3.3K27 methylation by altering the target search dynamics of PcG proteins.

Bibliographic Details
Main Authors: Roubina Tatavosian, Huy Nguyen Duc, Thao Ngoc Huynh, Dong Fang, Benjamin Schmitt, Xiaodong Shi, Yiming Deng, Christopher Phiel, Tingting Yao, Zhiguo Zhang, Haobin Wang, Xiaojun Ren
Format: Article
Language:English
Published: Nature Portfolio 2018-05-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-018-04455-7

Internet

https://doi.org/10.1038/s41467-018-04455-7

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