Irisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis

Irisin enhances chondrogenic differentiation of human mesenchymal stem cells via Rap1/PI3K/AKT axis

Abstract Background Human mesenchymal stem cells (hMSCs) have been proven to have inherent chondrogenic differentiation potential, which appears to be used in cartilage regeneration. Increasing evidence suggests that irisin enhances osteoblast differentiation of MSCs, but little is known about its p...

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Bibliographic Details
Main Authors: Taiqiu Chen, Yan Peng, Wenjun Hu, Huihong Shi, Pengfei Li, Yichen Que, Jincheng Qiu, Xianjian Qiu, Bo Gao, Hang Zhou, Yanbo Chen, Yuanxin Zhu, Shaoguang Li, Anjing Liang, Wenjie Gao, Dongsheng Huang
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Stem Cell Research & Therapy
Subjects:
Irisin
Human mesenchymal stem cells
Chondrogenic differentiation
Rap1/PI3K/AKT signaling pathway
SIPA1L2
miR-125b-5p
Online Access:https://doi.org/10.1186/s13287-022-03092-8

Internet

https://doi.org/10.1186/s13287-022-03092-8

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