Prognostic heterogeneity and clonal dynamics within distinct subgroups of myelodysplastic syndrome and acute myeloid leukemia with TP53 disruptions

Prognostic heterogeneity and clonal dynamics within distinct subgroups of myelodysplastic syndrome and acute myeloid leukemia with TP53 disruptions

Abstract TP53 aberrations constitute the highest risk subset of myelodysplastic neoplasms (MDS) and acute myeloid leukemia (AML). The International Consensus Classification questions the blast threshold between MDS and AML. In this study, we assess the distinction between MDS and AML for 76 patients...

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Bibliographic Details
Main Authors: Shyam A. Patel, Jan Cerny, William K. Gerber, Muthalagu Ramanathan, Asiri Ediriwickrema, Benjamin Tanenbaum, Lloyd Hutchinson, Xiuling Meng, Julie Flahive, Bruce Barton, Andrew J. Gillis‐Smith, Sakiko Suzuki, Salwa Khedr, William Selove, Anne W. Higgins, Patricia M. Miron, Karl Simin, Bruce Woda, Jonathan M. Gerber
Format: Article
Language:English
Published: Wiley 2023-11-01
Series:eJHaem
Subjects:
TP53
myelodysplastic syndrome
acute myeloid leukemia
hematopoietic stem cell
clonal dynamics
Online Access:https://doi.org/10.1002/jha2.791

Internet

https://doi.org/10.1002/jha2.791

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