Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation

Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation

Abstract Background Increasing evidence has shown that the mammalian target of rapamycin (mTOR) pathway plays a critical role in oocyte meiosis and embryonic development, however, previous studies reporting the effects of rapamycin on oocyte IVM showed different or even opposite results, and the spe...

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Bibliographic Details
Main Authors: Qiyu Yang, Qingsong Xi, Meng Wang, Rui Long, Juan Hu, Zhou Li, Xinling Ren, Lixia Zhu, Lei Jin
Format: Article
Language:English
Published: BMC 2022-04-01
Series:Reproductive Biology and Endocrinology
Subjects:
In vitro maturation
Rapamycin
mTOR
Oocyte quality
DNA damage
Online Access:https://doi.org/10.1186/s12958-022-00943-0

Internet

https://doi.org/10.1186/s12958-022-00943-0

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