Lower Metabolic Potential and Impaired Metabolic Flexibility in Human Lymph Node Stromal Cells from Patients with Rheumatoid Arthritis

Lower Metabolic Potential and Impaired Metabolic Flexibility in Human Lymph Node Stromal Cells from Patients with Rheumatoid Arthritis

Cellular metabolism is important for determining cell function and shaping immune responses. Studies have shown a crucial role for stromal cells in steering proper immune responses in the lymph node microenvironment. These lymph node stromal cells (LNSCs) tightly regulate immune tolerance. We hypoth...

Full description

Bibliographic Details
Main Authors: Tineke A. de Jong, Johanna F. Semmelink, Simone W. Denis, Janne W. Bolt, Mario Maas, Marleen G. H. van de Sande, Riekelt H. L. Houtkooper, Lisa G. M. van Baarsen
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Cells
Subjects:
autoimmunity
RA-risk individuals
lymph node stromal cells (LNSCs)
mitochondrial respiration
Online Access:https://www.mdpi.com/2073-4409/12/1/1

Internet

https://www.mdpi.com/2073-4409/12/1/1

Similar Items