Noninvasive assessment of dofetilide plasma concentration using a deep learning (neural network) analysis of the surface electrocardiogram: A proof of concept study.

Noninvasive assessment of dofetilide plasma concentration using a deep learning (neural network) analysis of the surface electrocardiogram: A proof of concept study.

BACKGROUND:Dofetilide is an effective antiarrhythmic medication for rhythm control in atrial fibrillation, but carries a significant risk of pro-arrhythmia and requires meticulous dosing and monitoring. The cornerstone of this monitoring, measurement of the QT/QTc interval, is an imperfect surrogate...

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Bibliographic Details
Main Authors: Zachi I Attia, Alan Sugrue, Samuel J Asirvatham, Michael J Ackerman, Suraj Kapa, Paul A Friedman, Peter A Noseworthy
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6104915?pdf=render

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http://europepmc.org/articles/PMC6104915?pdf=render

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