Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

Reduced GFAP Expression in Bergmann Glial Cells in the Cerebellum of Sigma-1 Receptor Knockout Mice Determines the Neurobehavioral Outcomes after Traumatic Brain Injury

Neuroprotective effects of Sigma-1 receptor (S1R) ligands have been observed in multiple animal models of neurodegenerative diseases. Traumatic brain injury (TBI)-related neurodegeneration can induce long-lasting physical, cognitive, and behavioral disabilities. The aim of our study was to evaluate...

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Bibliographic Details
Main Authors: Gundega Stelfa, Edijs Vavers, Baiba Svalbe, Rinalds Serzants, Anna Miteniece, Lasma Lauberte, Solveiga Grinberga, Baiba Gukalova, Maija Dambrova, Liga Zvejniece
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
sigma-1 receptor
traumatic brain injury
lateral fluid percussion injury
neurobehavior
cerebellum
astrocytes
Online Access:https://www.mdpi.com/1422-0067/22/21/11611

Internet

https://www.mdpi.com/1422-0067/22/21/11611

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