NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5

NRF3 suppresses squamous carcinogenesis, involving the unfolded protein response regulator HSPA5

Abstract Epithelial skin cancers are extremely common, but the mechanisms underlying their malignant progression are still poorly defined. Here, we identify the NRF3 transcription factor as a tumor suppressor in the skin. NRF3 protein expression is strongly downregulated or even absent in invasively...

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Bibliographic Details
Main Authors: Selina Gurri, Beat Siegenthaler, Michael Cangkrama, Gaetana Restivo, Marcel Huber, James Saliba, Reinhard Dummer, Volker Blank, Daniel Hohl, Sabine Werner
Format: Article
Language:English
Published: Springer Nature 2023-10-01
Series:EMBO Molecular Medicine
Subjects:
HSPA5
malignancy
NRF3
skin carcinogenesis
unfolded protein response
Online Access:https://doi.org/10.15252/emmm.202317761

Internet

https://doi.org/10.15252/emmm.202317761

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