Inhibition of mitochondrial complex II alters striatal expression of genes involved in glutamatergic and dopaminergic signaling: possible implications for Huntington's disease

Inhibition of mitochondrial complex II alters striatal expression of genes involved in glutamatergic and dopaminergic signaling: possible implications for Huntington's disease

Huntington's disease (HD) is a genetic neurodegenerative disorder characterized by motor abnormalities and cognitive impairment. The irreversible succinate dehydrogenase (SD) inhibitor 3-nitropropionic acid (3NP) causes neurodegeration in the striatum resembling HD when administered to rodents...

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Bibliographic Details
Main Authors: Maddalena Napolitano, Diego Centonze, Paolo Gubellini, Silvia Rossi, Stefania Spiezia, Giorgio Bernardi, Alberto Gulino, Paolo Calabresi
Format: Article
Language:English
Published: Elsevier 2004-03-01
Series:Neurobiology of Disease
Subjects:
3-Nitropropionic acid
Basal ganglia
cDNA microarrays
DARPP-32
Huntington's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996103002602

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http://www.sciencedirect.com/science/article/pii/S0969996103002602

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