Matrix metalloproteinase gene polymorphisms and bronchopulmonary dysplasia: identification of MMP16 as a new player in lung development.

BACKGROUND: Alveolarization requires coordinated extracellular matrix remodeling, a process in which matrix metalloproteinases (MMPs) play an important role. We postulated that polymorphisms in MMP genes might affect MMP function in preterm lungs and thus influence the risk of bronchopulmonary dyspl...

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Main Authors: Alice Hadchouel, Fabrice Decobert, Marie-Laure Franco-Montoya, Isabelle Halphen, Pierre-Henri Jarreau, Olivier Boucherat, Emmanuel Martin, Alexandra Benachi, Serge Amselem, Jacques Bourbon, Claude Danan, Christophe Delacourt
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2008-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2527515?pdf=render