Vaccine Based on Dendritic Cells Electroporated with an Exogenous Ovalbumin Protein and Pulsed with Invariant Natural Killer T Cell Ligands Effectively Induces Antigen-Specific Antitumor Immunity

Vaccine Based on Dendritic Cells Electroporated with an Exogenous Ovalbumin Protein and Pulsed with Invariant Natural Killer T Cell Ligands Effectively Induces Antigen-Specific Antitumor Immunity

(1) Background: Cancer vaccines are administered to induce cytotoxic CD8<sup>+</sup> T cells (CTLs) specific for tumor antigens. Invariant natural killer T (iNKT) cells, the specific T cells activated by α-galactosylceramide (α-GalCer), play important roles in this process as they are in...

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Bibliographic Details
Main Authors: Akihiro Watanabe, Kimihiro Yamashita, Mitsugu Fujita, Akira Arimoto, Masayasu Nishi, Shiki Takamura, Masafumi Saito, Kota Yamada, Kyosuke Agawa, Tomosuke Mukoyama, Masayuki Ando, Shingo Kanaji, Takeru Matsuda, Taro Oshikiri, Yoshihiro Kakeji
Format: Article
Language:English
Published: MDPI AG 2021-12-01
Series:Cancers
Subjects:
antitumor immunity
iNKT cell-enhanced vaccine
dendritic cells
electroporation
tissue-resident memory T cells
Online Access:https://www.mdpi.com/2072-6694/14/1/171

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https://www.mdpi.com/2072-6694/14/1/171

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