Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus

Potential capacity of interferon-α to eliminate covalently closed circular DNA (cccDNA) in hepatocytes infected with hepatitis B virus

Abstract Interferon-alpha (IFN-α) and nucleot(s)ide analogs (NAs) are first-line drugs for the treatment of chronic hepatitis B virus (HBV) infections. Generally, NAs target the reverse transcription of HBV pregenomic RNA, but they cannot eliminate covalently-closed-circular DNA (cccDNA). Although e...

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Bibliographic Details
Main Authors: Gang Wang, Jun Guan, Nazif U. Khan, Guojun Li, Junwei Shao, Qihui Zhou, Lichen Xu, Chunhong Huang, Jingwen Deng, Haihong Zhu, Zhi Chen
Format: Article
Language:English
Published: BMC 2021-04-01
Series:Gut Pathogens
Subjects:
Hepatitis B virus
interferon-α
Covalently closed circular DNA (cccDNA)
Chronic HBV infection
Deamination
Online Access:https://doi.org/10.1186/s13099-021-00421-9

Internet

https://doi.org/10.1186/s13099-021-00421-9

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