Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes

Inhibitors of Deubiquitinating Enzymes Block HIV-1 Replication and Augment the Presentation of Gag-Derived MHC-I Epitopes

In recent years it has been well established that two major constituent parts of the ubiquitin proteasome system (UPS)—the proteasome holoenzymes and a number of ubiquitin ligases—play a crucial role, not only in virus replication but also in the regulation of the immunogenicity of human immunodefic...

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Bibliographic Details
Main Authors: Christian Setz, Melanie Friedrich, Pia Rauch, Kirsten Fraedrich, Alina Matthaei, Maximilian Traxdorf, Ulrich Schubert
Format: Article
Language:English
Published: MDPI AG 2017-08-01
Series:Viruses
Subjects:
HIV-1
DUB-inhibitors
UPS
DUBs
ubiquitination
MHC-I
proteasome inhibitors
Online Access:https://www.mdpi.com/1999-4915/9/8/222

Internet

https://www.mdpi.com/1999-4915/9/8/222

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