Integration of National Health Insurance claims data and animal models reveals fexofenadine as a promising repurposed drug for Parkinson’s disease

Integration of National Health Insurance claims data and animal models reveals fexofenadine as a promising repurposed drug for Parkinson’s disease

Abstract Background Parkinson’s disease (PD) is a common and costly progressive neurodegenerative disease of unclear etiology. A disease-modifying approach that can directly stop or slow its progression remains a major unmet need in the treatment of PD. A clinical pharmacology-based drug repositioni...

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Bibliographic Details
Main Authors: Jae-Bong Kim, Yujeong Kim, Soo-Jeong Kim, Tae‑Young Ha, Dong-Kyu Kim, Dong Won Kim, Minyoung So, Seung Ho Kim, Hyun Goo Woo, Dukyong Yoon, Sang Myun Park
Format: Article
Language:English
Published: BMC 2024-02-01
Series:Journal of Neuroinflammation
Subjects:
Parkinson’s disease
α-Synuclein
Drug repositioning
Antihistamine
Fexofenadine
Online Access:https://doi.org/10.1186/s12974-024-03041-7

Internet

https://doi.org/10.1186/s12974-024-03041-7

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