High-Speed Imaging Reveals Opposing Effects of Chronic Stress and Antidepressants on Neuronal Activity Propagation through the Hippocampal Trisynaptic Circuit

High-Speed Imaging Reveals Opposing Effects of Chronic Stress and Antidepressants on Neuronal Activity Propagation through the Hippocampal Trisynaptic Circuit

Antidepressants (ADs) are used as first-line treatment for most stress-related psychiatric disorders. The alterations in brain circuit dynamics that can arise from stress exposure and underlie therapeutic actions of ADs remain, however, poorly understood. Here, enabled by a recently developed voltag...

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Bibliographic Details
Main Authors: Jens eStepan, Florian eHladky, Andrés eUribe, Florian eHolsboer, Mathias V. Schmidt, Matthias eEder
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-11-01
Series:Frontiers in Neural Circuits
Subjects:
Hippocampus
Ketamine
imaging
stress
Antidepressants
voltage-sensitive dye
Online Access:http://journal.frontiersin.org/Journal/10.3389/fncir.2015.00070/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fncir.2015.00070/full

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