Angiogenic effects of cell therapy within a biomaterial scaffold in a rat hind limb ischemia model

Abstract Critical limb ischemia (CLI) is a life- and limb-threatening condition affecting 1–10% of humans worldwide with peripheral arterial disease. Cellular therapies, such as bone marrow-derived mesenchymal stem cells (MSCs) have been used for the treatment of CLI. However, little information is...

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Bibliographic Details
Main Authors: Saeede Amani, Rasoul Shahrooz, Rahim Hobbenaghi, Rahim Mohammadi, Ali Baradar Khoshfetrat, Ali Karimi, Zahra Bakhtiari, Ian M. Adcock, Esmaeil Mortaz
Format: Article
Language:English
Published: Nature Portfolio 2021-10-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-021-99579-0