Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene
A single-nucleotide polymorphism (SNP) upstream of interleukin (IL)28B was recently identified as an important predictor of the outcome of chronic hepatitis C patients treated with pegylated interferon plus ribavirin (PEG-IFN/RBV). The aim of this study was to investigate the association between the...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Fundação Oswaldo Cruz (FIOCRUZ)
2013-02-01
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| Series: | Memorias do Instituto Oswaldo Cruz |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000100008 |
| _version_ | 1827879715624452096 |
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| author | Tarciana Grandi Cláudia Maria Dornelles da Silva Karine Medeiros Amaral Paulo Dornelles Picon Cintia Costi Nicole Nascimento da Fré Marilu Fiegenbaum Christian Niel Maria Lucia Rosa Rossetti |
| author_facet | Tarciana Grandi Cláudia Maria Dornelles da Silva Karine Medeiros Amaral Paulo Dornelles Picon Cintia Costi Nicole Nascimento da Fré Marilu Fiegenbaum Christian Niel Maria Lucia Rosa Rossetti |
| author_sort | Tarciana Grandi |
| collection | DOAJ |
| description | A single-nucleotide polymorphism (SNP) upstream of interleukin (IL)28B was recently identified as an important predictor of the outcome of chronic hepatitis C patients treated with pegylated interferon plus ribavirin (PEG-IFN/RBV). The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological response in chronic hepatitis C patients. Brazilian patients (n = 263) who were infected with hepatitis C virus (HCV) genotype 1 and were receiving PEG-IFN/RBV were genotyped. Early virological response (EVR) (12 weeks), end-of-treatment response (EOTR) (48 weeks), sustained virological response (SVR) (72 weeks) and relapse were evaluated using conventional and quantitative polymerase chain reaction (PCR) assays. The frequency of the C allele in the population was 39%. Overall, 43% of patients experienced SVR. The IL28B CC genotype was significantly associated with higher treatment response rates and a lower relapse rate compared to the other genotypes [84% vs. 58% EVR, 92% vs. 63% EOTR, 76% vs. 38% SVR and 17% vs. 40% relapse rate in CC vs. other genotypes (CT and TT), respectively]. Thus, the IL28B genotype appears to be a strong predictor of SVR following PEG-IFN/RBV therapy in treatment-naïve Brazilian patients infected with HCV genotype 1. This study, together with similar research examining other SNPs, should help to define adequate protocols for the treatment of patients infected with HCV genotype 1, especially those with a poor prognosis. |
| first_indexed | 2024-03-12T18:10:23Z |
| format | Article |
| id | doaj.art-70e80340db0b4e47802024998359def2 |
| institution | Directory Open Access Journal |
| issn | 0074-0276 1678-8060 |
| language | English |
| last_indexed | 2024-03-12T18:10:23Z |
| publishDate | 2013-02-01 |
| publisher | Fundação Oswaldo Cruz (FIOCRUZ) |
| record_format | Article |
| series | Memorias do Instituto Oswaldo Cruz |
| spelling | doaj.art-70e80340db0b4e47802024998359def22023-08-02T09:15:52ZengFundação Oswaldo Cruz (FIOCRUZ)Memorias do Instituto Oswaldo Cruz0074-02761678-80602013-02-0110814853Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B geneTarciana GrandiCláudia Maria Dornelles da SilvaKarine Medeiros AmaralPaulo Dornelles PiconCintia CostiNicole Nascimento da FréMarilu FiegenbaumChristian NielMaria Lucia Rosa RossettiA single-nucleotide polymorphism (SNP) upstream of interleukin (IL)28B was recently identified as an important predictor of the outcome of chronic hepatitis C patients treated with pegylated interferon plus ribavirin (PEG-IFN/RBV). The aim of this study was to investigate the association between the IL28B gene polymorphism (rs12979860) and virological response in chronic hepatitis C patients. Brazilian patients (n = 263) who were infected with hepatitis C virus (HCV) genotype 1 and were receiving PEG-IFN/RBV were genotyped. Early virological response (EVR) (12 weeks), end-of-treatment response (EOTR) (48 weeks), sustained virological response (SVR) (72 weeks) and relapse were evaluated using conventional and quantitative polymerase chain reaction (PCR) assays. The frequency of the C allele in the population was 39%. Overall, 43% of patients experienced SVR. The IL28B CC genotype was significantly associated with higher treatment response rates and a lower relapse rate compared to the other genotypes [84% vs. 58% EVR, 92% vs. 63% EOTR, 76% vs. 38% SVR and 17% vs. 40% relapse rate in CC vs. other genotypes (CT and TT), respectively]. Thus, the IL28B genotype appears to be a strong predictor of SVR following PEG-IFN/RBV therapy in treatment-naïve Brazilian patients infected with HCV genotype 1. This study, together with similar research examining other SNPs, should help to define adequate protocols for the treatment of patients infected with HCV genotype 1, especially those with a poor prognosis.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000100008IL28BHCVvirological responsetreatmentBrazil |
| spellingShingle | Tarciana Grandi Cláudia Maria Dornelles da Silva Karine Medeiros Amaral Paulo Dornelles Picon Cintia Costi Nicole Nascimento da Fré Marilu Fiegenbaum Christian Niel Maria Lucia Rosa Rossetti Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene Memorias do Instituto Oswaldo Cruz IL28B HCV virological response treatment Brazil |
| title | Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
| title_full | Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
| title_fullStr | Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
| title_full_unstemmed | Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
| title_short | Response to treatment in Brazilian patients with chronic hepatitis C is associated with a single-nucleotide polymorphism near the interleukin-28B gene |
| title_sort | response to treatment in brazilian patients with chronic hepatitis c is associated with a single nucleotide polymorphism near the interleukin 28b gene |
| topic | IL28B HCV virological response treatment Brazil |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0074-02762013000100008 |
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