Glioma Cell Migration on Three-dimensional Nanofiber Scaffolds Is Regulated by Substrate Topography and Abolished by Inhibition of STAT3 Signaling

Glioma Cell Migration on Three-dimensional Nanofiber Scaffolds Is Regulated by Substrate Topography and Abolished by Inhibition of STAT3 Signaling

A hallmark of malignant gliomas is their ability to disperse through neural tissue, leading to long-term failure of all known therapies. Identifying new antimigratory targets could reduce glioma recurrence and improve therapeutic efficacy, but screens based on conventional migration assays are hampe...

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Bibliographic Details
Main Authors: Paula A. Agudelo-Garcia, Jessica K. De Jesus, Shante P. Williams, Michal O. Nowicki, Ennio Antonio Chiocca, Sandya Liyanarachchi, Pui-Kai Li, John J. Lannutti, Jed K. Johnson, Sean E. Lawler, Mariano S. Viapiano
Format: Article
Language:English
Published: Elsevier 2011-09-01
Series:Neoplasia: An International Journal for Oncology Research
Online Access:http://www.sciencedirect.com/science/article/pii/S1476558611800357

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http://www.sciencedirect.com/science/article/pii/S1476558611800357

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