Energy Starvation Induces a Cell Cycle Arrest in Escherichia coli by Triggering Degradation of the DnaA Initiator Protein

Energy Starvation Induces a Cell Cycle Arrest in Escherichia coli by Triggering Degradation of the DnaA Initiator Protein

During steady-state Escherichia coli growth, the amount and activity of the initiator protein, DnaA, controls chromosome replication tightly so that initiation only takes place once per origin in each cell cycle, regardless of growth conditions. However, little is known about the mechanisms involved...

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Bibliographic Details
Main Authors: Godefroid Charbon, Belén Mendoza-Chamizo, Christopher Campion, Xiaobo Li, Peter Ruhdal Jensen, Jakob Frimodt-Møller, Anders Løbner-Olesen
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Molecular Biosciences
Subjects:
Escherichia coli
chromosome replication
initiation
DnaA protein
degradation
energy starvation
Online Access:https://www.frontiersin.org/articles/10.3389/fmolb.2021.629953/full

Internet

https://www.frontiersin.org/articles/10.3389/fmolb.2021.629953/full

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