Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations

Altered microRNA expression in frontotemporal lobar degeneration with TDP-43 pathology caused by progranulin mutations

<p>Abstract</p> <p>Background</p> <p>Frontotemporal lobar degeneration (FTLD) is a progressive neurodegenerative disorder that can be triggered through genetic or sporadic mechanisms. MicroRNAs (miRNAs) have become a major therapeutic focus as their pervasive expression...

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Bibliographic Details
Main Authors: Kocerha Jannet, Kouri Naomi, Baker Matt, Finch NiCole, DeJesus-Hernandez Mariely, Gonzalez John, Chidamparam Kumaravel, Josephs Keith A, Boeve Bradley F, Graff-Radford Neill R, Crook Julia, Dickson Dennis W, Rademakers Rosa
Format: Article
Language:English
Published: BMC 2011-10-01
Series:BMC Genomics
Subjects:
Frontotemporal lobar degeneration
TDP-43
microRNA
progranulin
Online Access:http://www.biomedcentral.com/1471-2164/12/527

Internet

http://www.biomedcentral.com/1471-2164/12/527

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