Synthesis of β-Enaminonitrile-Linked 8-Methoxy-1H-Benzo[f]Chromene Moieties and Analysis of Their Antitumor Mechanisms

Synthesis of β-Enaminonitrile-Linked 8-Methoxy-1H-Benzo[f]Chromene Moieties and Analysis of Their Antitumor Mechanisms

A series of aryl-substituted 3-amino-1-aryl-8-methoxy-1H-benzo[f]chromene-2-carbonitriles (4a–4q) were designed and synthesized via reaction of 6-methoxy-2-naphthol with a mixture of appropriate aromatic aldehydes and malononitrile under microwave conditions. The structures of the novel compounds 4b...

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Bibliographic Details
Main Authors: Menna Elgaafary, Ahmed M. Fouda, Hany M. Mohamed, Abdelaaty Hamed, Heba K. A. El-Mawgoud, Lu Jin, Judith Ulrich, Thomas Simmet, Tatiana Syrovets, Ahmed M. El-Agrody
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Chemistry
Subjects:
1H-benzo[f]chromenes
cell cycle
caspase 3/7
reactive oxygen species (ROS)
mitochondrial membrane potential
structure–activity relationship
Online Access:https://www.frontiersin.org/articles/10.3389/fchem.2021.759148/full

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https://www.frontiersin.org/articles/10.3389/fchem.2021.759148/full

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