Red blood cell metabolomics identify ergothioneine as a key metabolite in DMARD-naïve rheumatoid arthritis and response to methotrexate

Red blood cell metabolomics identify ergothioneine as a key metabolite in DMARD-naïve rheumatoid arthritis and response to methotrexate

Abstract Using a new red blood cell (RBC) metabolite extraction protocol, we performed a metabolomic analysis on RBCs in rheumatoid arthritis (RA) patients treated or not with methotrexate (MTX), with the two following objectives: to compare the RBC metabolic profiles of MTX-naïve RA patients and he...

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Bibliographic Details
Main Authors: Johanna Sigaux, Christophe Junot, Marie-Christophe Boissier, Mylène Petit, Magali Breckler, Florence Castelli, François Fenaille, Paul-Henri Roméo, Luca Semerano
Format: Article
Language:English
Published: Nature Portfolio 2024-09-01
Series:Scientific Reports
Subjects:
Rheumatoid arthritis
Metabolomic
Ergothioneine
Diet
Environment
Online Access:https://doi.org/10.1038/s41598-024-68477-6

Internet

https://doi.org/10.1038/s41598-024-68477-6

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