A Rapid, Simple, Trace, Cost-Effective, and High-Throughput Stable Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry Method for Serum Methylmalonic Acid Quantification and Its Clinical Applications

A Rapid, Simple, Trace, Cost-Effective, and High-Throughput Stable Isotope-Dilution Liquid Chromatography–Tandem Mass Spectrometry Method for Serum Methylmalonic Acid Quantification and Its Clinical Applications

Background: Methylmalonic acid (MMA) is an essential indicator of vitamin B12 (VB12) deficiency and inherited metabolic disorders (IMDs). The increasing number of requests for MMA testing call for higher requirements for convenient MMA testing methods. This study aims to develop a convenient quantif...

Full description

Bibliographic Details
Main Authors: Lizi Jin, Zhenni Liu, Weiyan Zhou, Jie Zeng, Minhang Wu, Yu Zhang, Tianjiao Zhang, Falin He, Chuanbao Zhang
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Diagnostics
Subjects:
liquid chromatography–tandem mass spectrometry
methylmalonic acid
vitamin B12 deficiency
method improvements
Online Access:https://www.mdpi.com/2075-4418/12/10/2273

Internet

https://www.mdpi.com/2075-4418/12/10/2273

Similar Items