Amelioration of Morphological Pathology in Cardiac, Respiratory, and Skeletal Muscles Following Intraosseous Administration of Human Dystrophin Expressing Chimeric (DEC) Cells in Duchenne Muscular Dystrophy Model

Amelioration of Morphological Pathology in Cardiac, Respiratory, and Skeletal Muscles Following Intraosseous Administration of Human Dystrophin Expressing Chimeric (DEC) Cells in Duchenne Muscular Dystrophy Model

Duchenne Muscular Dystrophy (DMD) is a lethal disease caused by mutation in the dystrophin gene. Currently there is no cure for DMD. We introduced a novel human Dystrophin Expressing Chimeric (DEC) cell therapy of myoblast origin and confirmed the safety and efficacy of DEC in the <i>mdx</i...

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Bibliographic Details
Main Authors: Maria Siemionow, Katarzyna Budzynska, Kristina Zalants, Paulina Langa, Sonia Brodowska, Krzysztof Siemionow, Ahlke Heydemann
Format: Article
Language:English
Published: MDPI AG 2024-03-01
Series:Biomedicines
Subjects:
Duchenne Muscular Dystrophy (DMD)
Dystrophin Expressing Chimeric (DEC) cells
DEC therapy
systemic-intraosseous administration
cardiac and skeletal muscle morphology
minimal Feret’s fiber diameter
Online Access:https://www.mdpi.com/2227-9059/12/3/586

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https://www.mdpi.com/2227-9059/12/3/586

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