SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression

SMC3 epigenetic silencing regulates Rab27a expression and drives pancreatic cancer progression

Abstract Background Pancreatic ductal adenocarcinoma (PDAC) is expected to soon surpass colorectal cancer as a leading cause of cancer mortality in both males and females in the US, only lagging behind lung cancer. The lethality of PDAC is driven by late diagnosis and inefficient therapies. The comp...

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Bibliographic Details
Main Authors: Nuno Bastos, Stéphanie A. Castaldo, Bárbara Adem, José C. Machado, Carlos A. Melo, Sonia A. Melo
Format: Article
Language:English
Published: BMC 2023-08-01
Series:Journal of Translational Medicine
Subjects:
Pancreatic cancer
Rab27a
Exosomes
SMC3
Online Access:https://doi.org/10.1186/s12967-023-04448-1

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