Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability

Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability

AimsExosomes (exo) are involved in the progression of osteoarthritis (OA). This study aimed to investigate the function of dysfunctional chondrocyte-derived exo (DC-exo) on OA in rats and rat macrophages.MethodsRat-derived chondrocytes were isolated, and DCs induced with interleukin (IL)-1β were use...

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Bibliographic Details
Main Authors: Guohua Lv, Bing Wang, Lei Li, Yunchao Li, Xinyi Li, Haoyu He, Lei Kuang
Format: Article
Language:English
Published: The British Editorial Society of Bone & Joint Surgery 2022-09-01
Series:Bone & Joint Research
Subjects:
Osteoarthritis
Dysfunctional chondrocyte-derived exosomes
Long non-coding RNA OANCT
PIK3R5
FTO
Osteoarthritis (OA)
Online Access:https://online.boneandjoint.org.uk/doi/10.1302/2046-3758.119.BJR-2021-0443.R2

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https://online.boneandjoint.org.uk/doi/10.1302/2046-3758.119.BJR-2021-0443.R2

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