Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability

Exosomes from dysfunctional chondrocytes affect osteoarthritis in Sprague-Dawley rats through FTO-dependent regulation of PIK3R5 mRNA stability

AimsExosomes (exo) are involved in the progression of osteoarthritis (OA). This study aimed to investigate the function of dysfunctional chondrocyte-derived exo (DC-exo) on OA in rats and rat macrophages.MethodsRat-derived chondrocytes were isolated, and DCs induced with interleukin (IL)-1β were use...

Full description

Bibliographic Details
Main Authors:	Guohua Lv, Bing Wang, Lei Li, Yunchao Li, Xinyi Li, Haoyu He, Lei Kuang
Format:	Article
Language:	English
Published:	The British Editorial Society of Bone & Joint Surgery 2022-09-01
Series:	Bone & Joint Research
Subjects:	Osteoarthritis Dysfunctional chondrocyte-derived exosomes Long non-coding RNA OANCT PIK3R5 FTO Osteoarthritis (OA)
Online Access:	https://online.boneandjoint.org.uk/doi/10.1302/2046-3758.119.BJR-2021-0443.R2

Similar Items

Infrapatellar Fat Pad Modulates Osteoarthritis-Associated Cytokine and MMP Expression in Human Articular Chondrocytes
by: Ewa Wisniewska, et al.
Published: (2023-12-01)

The rs1477196 SNP of the FTO Gene is Associated with Primary Knee Osteoarthritis in a Female Population from Northern Mexico
by: Rubén D. Arellano-Pérez-Vertti, et al.
Published: (2024-01-01)

Long Noncoding RNA CIR Promotes Chondrocyte Extracellular Matrix Degradation in Osteoarthritis by Acting as a Sponge For Mir-27b
by: Yu-Fei Li, et al.
Published: (2017-09-01)

The Nrf2/HMGB1/NF-κB axis modulates chondrocyte apoptosis and extracellular matrix degradation in osteoarthritis
by: Li Wenzhao, et al.
Published: (2023-05-01)

CircSFMBT2-OA alleviates chondrocyte apoptosis and extracellular matrix degradation through repressing NF-κB/NLRP3 inflammasome activation
by: Axiang He, et al.
Published: (2023-06-01)

S-Equol Protects Chondrocytes against Sodium Nitroprusside-Caused Matrix Loss and Apoptosis through Activating PI<sub>3</sub>K/Akt Pathway
by: Li-Wen Huang, et al.
Published: (2021-06-01)

Pathological perspective of chondrocyte apoptosis in osteoarthritis
by: Abhijeet Kunwar, et al.
Published: (2017-01-01)

Rapamycin Inhibits Nf-ΚB Activation by Autophagy to Reduce Catabolism in Human Chondrocytes
by: Yibin Liu, et al.
Published: (2020-10-01)

PTH (1-34) enhances the therapeutic effect of bone marrow mesenchymal stem cell-derived exosomes by inhibiting proinflammatory cytokines expression on OA chondrocyte repair in vitro
by: Li-tao Shao, et al.
Published: (2022-04-01)

Exosomes derived from platelet-rich plasma present a novel potential in alleviating knee osteoarthritis by promoting proliferation and inhibiting apoptosis of chondrocyte via Wnt/β-catenin signaling pathway
by: Xuchang Liu, et al.
Published: (2019-12-01)

Cyclooxygenase-2 regulates PTHrP transcription in human articular chondrocytes and is involved in the pathophysiology of osteoarthritis in rats
by: Ling-hua Chang, et al.
Published: (2021-09-01)

EFFECT OF PLATELET RICH PLASMA ON CHONDROCYTE NUMBER IN CHEMICALLY INDUCED ANIMAL MODEL OF OSTEOARTHRITIS
by: Rafia Asjid, et al.
Published: (2019-06-01)

Human Bone Mesenchymal Stem Cell-Derived Exosomes Inhibit IL-1β-Induced Inflammation in Osteoarthritis Chondrocytes
by: Liping Zhou, et al.
Published: (2021-09-01)

Proliferation and Anti-inflammatory Effects of Tremella fuciformis Polysaccharide on Human Chondrocytes
by: Minying TAN, et al.
Published: (2024-01-01)

Experimental observation of the sequence of tibial plateau chondrocyte and matrix degeneration in spontaneous osteoarthritis in Guinea pigs
by: Xiao-jian Wang, et al.
Published: (2021-04-01)

Mitochondrial dependent pathway is involved in the protective effects of carboxymethylated chitosan on nitric oxide-induced apoptosis in chondrocytes
by: Bin He, et al.
Published: (2020-01-01)

Glutamine metabolism modulates chondrocyte inflammatory response
by: Manoj Arra, et al.
Published: (2022-08-01)

Osteoarthritic chondrocytes undergo a glycolysis-related metabolic switch upon exposure to IL-1b or TNF
by: Anais Defois, et al.
Published: (2023-06-01)

Lactoferrin Inhibits IL-1β-Induced Chondrocyte Apoptosis Through AKT1-Induced CREB1 Activation
by: Huaming Xue, et al.
Published: (2015-07-01)

Oxytocin Controls Chondrogenesis and Correlates with Osteoarthritis
by: Christian H. Roux, et al.
Published: (2020-05-01)

Tert-butylhydroquinone attenuates osteoarthritis by protecting chondrocytes and inhibiting macrophage polarization
by: Hua Zhang, et al.
Published: (2021-11-01)

Epigenetic regulation of chondrocytes affected by mitochondria through mechanotransduction in osteoarthritis
by: Tianyou Kan, et al.
Published: (2023-06-01)

Sakuranetin reduces inflammation and chondrocyte dysfunction in osteoarthritis by inhibiting the PI3K/AKT/NF-κB pathway
by: Xiaofeng Deng, et al.
Published: (2024-02-01)

The oncofetal gene survivin is re-expressed in osteoarthritis and is required for chondrocyte proliferation <it>in vitro</it>
by: Baier Clemens, et al.
Published: (2011-07-01)

Effects of mechanical stimulation on metabolomic profiles of SW1353 chondrocytes: shear and compression
by: Hope D. Welhaven, et al.
Published: (2022-01-01)

Irisin Recovers Osteoarthritic Chondrocytes In Vitro
by: Gianluca Vadalà, et al.
Published: (2020-06-01)

In Vitro Study of Licorice on IL-1β-Induced Chondrocytes and In Silico Approach for Osteoarthritis
by: Akhtar Ali, et al.
Published: (2021-12-01)

Pleiotropic Roles of NOTCH1 Signaling in the Loss of Maturational Arrest of Human Osteoarthritic Chondrocytes
by: Manuela Minguzzi, et al.
Published: (2021-11-01)

Neural cell adhesion molecule regulates chondrocyte hypertrophy in chondrogenic differentiation and experimental osteoarthritis
by: Bin‐Feng Cheng, et al.
Published: (2020-02-01)

Up-regulation of long non-coding RNA CYTOR induced by icariin promotes the viability and inhibits the apoptosis of chondrocytes
by: Guoyou Wang, et al.
Published: (2021-05-01)

The Level of Histone Deacetylase 4 is Associated with Aging Cartilage Degeneration and Chondrocyte Hypertrophy
by: Dong Z, et al.
Published: (2022-06-01)

Boswellic acid captivated hydroxyapatite carboxymethyl cellulose composites for the enhancement of chondrocytes in cartilage repair
by: Dianhai Bi, et al.
Published: (2020-06-01)

The Role of Chondrocyte Hypertrophy and Senescence in Osteoarthritis Initiation and Progression
by: Yeri Alice Rim, et al.
Published: (2020-03-01)

Circ_0045714/miR-331-3p interaction affects IL-1β-evoked human articular chondrocyte injury through regulating PIK3R3 in a ceRNA regulatory cascade
by: Ran Ding, et al.
Published: (2021-10-01)

Autophagy tunes chondrocyte differentiation and joint developmental precision in zebrafish
by: Joanna J. Moss, et al.
Published: (2022-12-01)

Development of an efficient vitrification method for chondrocyte sheets for clinical application
by: Asuka Hayashi, et al.
Published: (2020-06-01)

Protective effects of ten oligostilbenes from Paeonia suffruticosa seeds on interleukin-1β-induced rabbit osteoarthritis chondrocytes
by: Yu-Kun He, et al.
Published: (2019-05-01)

Osteoarthritis as an Umbrella Term for Different Subsets of Humans Undergoing Joint Degeneration: The Need to Address the Differences to Develop Effective Conservative Treatments and Prevention Strategies
by: David A. Hart
Published: (2022-12-01)

Analyses of Transcriptomics upon IL-1β-Stimulated Mouse Chondrocytes and the Protective Effect of Catalpol through the NOD2/NF-κB/MAPK Signaling Pathway
by: Yong Pang, et al.
Published: (2023-02-01)

Recent Therapeutic Strategies for Excessive Chondrocyte Death in Osteoarthritis: A Review
by: Wei Xiang, et al.
Published: (2023-06-01)