FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion

FXR1 regulates transcription and is required for growth of human cancer cells with TP53/FXR2 homozygous deletion

Tumor suppressor p53 prevents cell transformation by inducing apoptosis and other responses. Homozygous TP53 deletion occurs in various types of human cancers for which no therapeutic strategies have yet been reported. TCGA database analysis shows that the TP53 homozygous deletion locus mostly exhib...

Full description

Bibliographic Details
Main Authors: Yichao Fan, Jiao Yue, Mengtao Xiao, Han Han-Zhang, Yao Vickie Wang, Chun Ma, Zhilin Deng, Yingxiang Li, Yanyan Yu, Xinghao Wang, Shen Niu, Youjia Hua, Zhiping Weng, Peter Atadja, En Li, Bin Xiang
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2017-08-01
Series:eLife
Subjects:
FXR1
p53 deletion
collateral lethality
fragile X family
STAT
Online Access:https://elifesciences.org/articles/26129

Internet

https://elifesciences.org/articles/26129

Similar Items