Loss of CD11b Accelerates Lupus Nephritis in Lyn-Deficient Mice Without Disrupting Glomerular Leukocyte Trafficking

Loss of CD11b Accelerates Lupus Nephritis in Lyn-Deficient Mice Without Disrupting Glomerular Leukocyte Trafficking

Systemic lupus erythematosus (SLE) is a complex, heterogeneous autoimmune disease. A common manifestation, lupus nephritis, arises from immune complex deposition in the kidney microvasculature promoting leukocyte activation and infiltration, which triggers glomerular damage and renal dysfunction. CD...

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Bibliographic Details
Main Authors: Timothy A. Gottschalk, Pamela Hall, Evelyn Tsantikos, Elan L’Estrange-Stranieri, Michael J. Hickey, Margaret L. Hibbs
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
systemic lupus erythematosus
glomerulonephritis
inflammation
myeloid cells
immune cell trafficking
Lyn tyrosine kinase
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.875359/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.875359/full

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