Identification of highly potent α-glucosidase inhibitors from Garcinia schomburgkiana and molecular docking studies

Identification of highly potent α-glucosidase inhibitors from Garcinia schomburgkiana and molecular docking studies

Twenty-two compounds (1-22) were isolated from the stems and twigs of Garcinia schomburgkiana. NMR, IR, UV, and MS were used for structural elucidation, and comparisons were made with previous reports. Compound 1 exhibited the most potent α-glucosidase inhibition (IC50 0.31 ± 0.7 μM), outperformin...

Full description

Bibliographic Details
Main Authors: Thi My Lien Do, Nguyen-Minh-An Tran, Thuc-Huy Duong, Preecha Phuwapraisirisan, Nakorn Niamnont, Kewalin Inthanon, Jirapast Sichaem, Suttira Sedlak
Format: Article
Language:English
Published: Prince of Songkla University 2021-12-01
Series:Songklanakarin Journal of Science and Technology (SJST)
Subjects:
clusiaceae
garcinia schomburgkiana
α-glucosidase inhibition
molecular docking calculation
Online Access:https://rdo.psu.ac.th/sjst/journal/43-6/9.pdf

Internet

https://rdo.psu.ac.th/sjst/journal/43-6/9.pdf

Similar Items