Atenolol reduces Leishmania major-induced hyperalgesia and TNF-alpha without affecting IL-1beta or keratinocyte derived chemokines (KC)

Atenolol reduces Leishmania major-induced hyperalgesia and TNF-alpha without affecting IL-1beta or keratinocyte derived chemokines (KC)

Infection with a high dose of the intracellular parasitic protozoan L. major induces a sustained hyperalgesia in susceptible BALB/c mice accompanied by up-regulation of the pro-inflammatory cytokines IL-1β and IL-6. Interleukin-13 (IL-13) has been shown to reduce this hyperalgesia (despite increased...

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Bibliographic Details
Main Authors: Marc eKaram, Rana eMerkabawi, Sara eSalman, Ali eMobasheri
Format: Article
Language:English
Published: Frontiers Media S.A. 2016-02-01
Series:Frontiers in Pharmacology
Subjects:
Atenolol
Chemokines
Hyperalgesia
Leishmania major
keratinocyte
TNF-α
Online Access:http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00022/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fphar.2016.00022/full

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