Glibenclamide-Loaded Engineered Nanovectors (GNVs) Modulate Autophagy and NLRP3-Inflammasome Activation

Glibenclamide-Loaded Engineered Nanovectors (GNVs) Modulate Autophagy and NLRP3-Inflammasome Activation

Activation of the NLRP3 inflammasome in response to either exogenous (PAMPs) or endogenous (DAMPs) stimuli results in the production of IL-18, caspase-1 and IL-1β. These cytokines have a beneficial role in promoting inflammation, but an excessive activation of the inflammasome and the consequent con...

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Bibliographic Details
Main Authors: Marina Saresella, Chiara Paola Zoia, Francesca La Rosa, Chiara Bazzini, Gessica Sala, Erica Grassenis, Ivana Marventano, Ambra Hernis, Federica Piancone, Elisa Conti, Silvia Sesana, Francesca Re, Pierfausto Seneci, Carlo Ferrarese, Mario Clerici
Format: Article
Language:English
Published: MDPI AG 2023-12-01
Series:Pharmaceuticals
Subjects:
autophagy
Glibenclamide-loaded engineered NanoVectors (GNVs)
NLRP3
Online Access:https://www.mdpi.com/1424-8247/16/12/1725

Internet

https://www.mdpi.com/1424-8247/16/12/1725

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