Effects of Metformin on Burn-Induced Hepatic Endoplasmic Reticulum Stress in Male Rats

Abstract Severe burn injury causes hepatic dysfunction that results in major metabolic derangements including insulin resistance and hyperglycemia and is associated with hepatic endoplasmic reticulum (ER) stress. We have recently shown that insulin reduces ER stress and improves liver function and m...

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Bibliographic Details
Main Authors: Yaeko Hiyama, Alexandra H. Marshall, Robert Kraft, Nour Qa’aty, Anna Arno, David N. Herndon, Marc G. Jeschke
Format: Article
Language:English
Published: BMC 2013-01-01
Series:Molecular Medicine
Subjects:
Online Access:https://doi.org/10.2119/molmed.2012.00330