Scalable Enrichment of Immunomodulatory Human Acute Myeloid Leukemia Cell Line-Derived Extracellular Vesicles

Scalable Enrichment of Immunomodulatory Human Acute Myeloid Leukemia Cell Line-Derived Extracellular Vesicles

Acute myeloid leukemia (AML) cells can secrete trophic factors, including extracellular vesicles (EVs), instructing the stromal leukemic niche. Here, we introduce a scalable workflow for purification of immunomodulatory AML-EVs to compare their phenotype and function to the parental AML cells and th...

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Bibliographic Details
Main Authors: Heide-Marie Binder, Nicole Maeding, Martin Wolf, André Cronemberger Andrade, Balazs Vari, Linda Krisch, Fausto Gueths Gomes, Constantin Blöchl, Katharina Muigg, Rodolphe Poupardin, Anna M. Raninger, Thomas Heuser, Astrid Obermayer, Patricia Ebner-Peking, Lisa Pleyer, Richard Greil, Christian G. Huber, Katharina Schallmoser, Dirk Strunk
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:Cells
Subjects:
acute myeloid leukemia (AML)
extracellular vesicles (EV)
immunomodulation
MISEV
Online Access:https://www.mdpi.com/2073-4409/10/12/3321

Internet

https://www.mdpi.com/2073-4409/10/12/3321

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