Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration

Genetic iron chelation protects against proteasome inhibition-induced dopamine neuron degeneration

Impairment of the ubiquitin proteasome system (UPS) and iron accumulation in the substantia nigra (SN) have both been implicated in the pathogenesis of Parkinson's disease (PD). We previously reported that chemical iron chelation can protect against proteasome inhibitor lactacystin-induced dopa...

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Bibliographic Details
Main Authors: Wen Zhu, Xuping Li, Wenjie Xie, Feifei Luo, Deepinder Kaur, Julie K. Andersen, Joseph Jankovic, Weidong Le
Format: Article
Language:English
Published: Elsevier 2010-02-01
Series:Neurobiology of Disease
Subjects:
Iron chelation
Ferritin
DMT1
UPS impairment
Parkinson's disease
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996109002769

Internet

http://www.sciencedirect.com/science/article/pii/S0969996109002769

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