Metformin enhances epithelial cell growth inhibition via the protein kinase–insulin-like growth factor binding protein-1 pathway

Metformin enhances epithelial cell growth inhibition via the protein kinase–insulin-like growth factor binding protein-1 pathway

AbstractBackground Abnormal stromal-epithelial cell communication is a pathogenic mechanism in endometriosis, and metformin can modulate it. Insulin-like growth factor binding protein-1 (IGFBP1) plays a role in endometriosis, but the exact mechanism is unknown. IGFBP1 is reportedly a downstream targ...

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Bibliographic Details
Main Authors: Xuping Shao, Changling Li, Junhui Liang, Li Changzhong
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Journal of Obstetrics and Gynaecology
Subjects:
Endometriosis
metformin
AMPK-IGFBP1
stromal–epithelial communication
PI3K-AKT
Online Access:https://www.tandfonline.com/doi/10.1080/01443615.2024.2321651

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https://www.tandfonline.com/doi/10.1080/01443615.2024.2321651

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