SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial Cells

SARS-CoV-2 Isolates Show Impaired Replication in Human Immune Cells but Differential Ability to Replicate and Induce Innate Immunity in Lung Epithelial Cells

ABSTRACT The primary target organ of coronavirus disease 2019 (COVID-19) infection is the respiratory tract. Currently, there is limited information on the ability of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) to infect and regulate innate immunity in human immune cells and lung ep...

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Bibliographic Details
Main Authors: Miao Jiang, Pekka Kolehmainen, Laura Kakkola, Sari Maljanen, Krister Melén, Teemu Smura, Ilkka Julkunen, Pamela Österlund
Format: Article
Language:English
Published: American Society for Microbiology 2021-09-01
Series:Microbiology Spectrum
Subjects:
SARS-CoV-2
COVID-19
viral replication
human macrophage
human DC
Calu-3 cell
Online Access:https://journals.asm.org/doi/10.1128/Spectrum.00774-21

Internet

https://journals.asm.org/doi/10.1128/Spectrum.00774-21

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