Photoactivation of TGFβ/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer’s disease model

Photoactivation of TGFβ/SMAD signaling pathway ameliorates adult hippocampal neurogenesis in Alzheimer’s disease model

Abstract Background Adult hippocampal neurogenesis (AHN) is restricted under the pathological conditions of neurodegenerative diseases, especially in Alzheimer’s disease (AD). The drop of AHN reduces neural circuit plasticity, resulting in the decrease of the generation of newborn neurons in dentate...

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Bibliographic Details
Main Authors: Xiaolei Wu, Qi Shen, Zhan Zhang, Di Zhang, Ying Gu, Da Xing
Format: Article
Language:English
Published: BMC 2021-06-01
Series:Stem Cell Research & Therapy
Subjects:
Adult hippocampal neurogenesis
Photobiomodulation therapy
Neural stem cell
Newborn neuron
Alzheimer’s disease model
TGFβ/Smad pathway
Online Access:https://doi.org/10.1186/s13287-021-02399-2

Internet

https://doi.org/10.1186/s13287-021-02399-2

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