Lack of Epileptogenic Effects of the Creatine Precursor Guanidinoacetic Acid on Neuronal Cultures In Vitro

Lack of Epileptogenic Effects of the Creatine Precursor Guanidinoacetic Acid on Neuronal Cultures In Vitro

The creatine precursor Guanidinoacetic Acid (GAA) accumulates in the genetic deficiency of the GuanidinoAcetate Methyl Transferase (GAMT) enzyme and it is believed to cause the seizures that often occur in this condition. However, evidence that it is indeed epileptogenic is scarce and we previously...

Full description

Bibliographic Details
Main Authors: Fabio Poggio, Martina Brofiga, Mariateresa Tedesco, Paolo Massobrio, Enrico Adriano, Maurizio Balestrino
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Biomolecules
Subjects:
guanidinoacetic acid
creatine
GAMT deficiency
seizures
epilepsy
electrophysiology
Online Access:https://www.mdpi.com/2218-273X/13/1/74

Internet

https://www.mdpi.com/2218-273X/13/1/74

Similar Items