miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

miR-146a-5p-modified hUCMSC-derived exosomes facilitate spinal cord function recovery by targeting neurotoxic astrocytes

Abstract Background Acute spinal cord injury (SCI) is a devastating result of neurological trauma with subsequent microenvironment dyshomeostasis that induces neurotoxic phenotype acquisition by astrocytes, exacerbating neurological function impairment. Exosomes derived from human umbilical cord mes...

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Bibliographic Details
Main Authors: Xunwei Lai, Yang Wang, Xiaokang wang, Bin Liu, Limin Rong
Format: Article
Language:English
Published: BMC 2022-09-01
Series:Stem Cell Research & Therapy
Subjects:
Modified exosomes
Neurotoxic astrocytes
Spinal cord injury
miR-146a-5p/Traf6/Irak1 axis
Online Access:https://doi.org/10.1186/s13287-022-03116-3

Internet

https://doi.org/10.1186/s13287-022-03116-3

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