The PAPSS1 gene is a modulator of response to cisplatin by regulating estrogen receptor alpha signaling activity in ovarian cancer cells

The PAPSS1 gene is a modulator of response to cisplatin by regulating estrogen receptor alpha signaling activity in ovarian cancer cells

Abstract Background Cancer cells may develop resistance to cisplatin by various mechanisms. Yet, the exact mechanism of cisplatin in ovarian cancer remains unclear. Recent studies have shown that 3’-phospoadenosine 5’-phosphosulfate synthase 1 (PAPSS1) inhibition combined with low-dose cisplatin inc...

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Bibliographic Details
Main Authors: Lei Sun, Wei-Xue Ji, Yan Li, Ze-Lian Li, Can-Can Duan, Bai-rong Xia, Lan Xiao
Format: Article
Language:English
Published: BMC 2023-09-01
Series:Journal of Ovarian Research
Subjects:
Epithelial ovarian cancer
Sulfation pathways
PAPSS1
Cisplatin resistance
Estradiol
Estrogen receptor alpha
Online Access:https://doi.org/10.1186/s13048-023-01262-7

Internet

https://doi.org/10.1186/s13048-023-01262-7

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