Low-Dose Naltrexone (LDN)—Review of Therapeutic Utilization

Naltrexone and naloxone are classical opioid antagonists. In substantially lower than standard doses, they exert different pharmacodynamics. Low-dose naltrexone (LDN), considered in a daily dose of 1 to 5 mg, has been shown to reduce glial inflammatory response by modulating Toll-like receptor 4 sig...

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Bibliographic Details
Main Authors: Karlo Toljan, Bruce Vrooman
Format: Article
Language:English
Published: MDPI AG 2018-09-01
Series:Medical Sciences
Subjects:
Online Access:http://www.mdpi.com/2076-3271/6/4/82