Structures of human plasma β–factor XIIa cocrystallized with potent inhibitors

Abstract: Activated factor XIIa (FXIIa) is a serine protease that has received a great deal of interest in recent years as a potential target for the development of new antithrombotics. Despite the strong interest in obtaining structural information, only the structure of the FXIIa catalytic domain...

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Bibliographic Details
Main Authors: Alexey Dementiev, Abel Silva, Calvin Yee, Zhe Li, Michael T. Flavin, Hing Sham, James R. Partridge
Format: Article
Language:English
Published: Elsevier 2018-03-01
Series:Blood Advances
Online Access:http://www.sciencedirect.com/science/article/pii/S2473952920310788