Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on α-Glucosidase Inhibitors and Their Molecular Docking

Synthesis of Novel Triazinoindole-Based Thiourea Hybrid: A Study on α-Glucosidase Inhibitors and Their Molecular Docking

A new class of triazinoindole-bearing thiosemicarbazides (<b>1</b>&#8722;<b>25</b>) was synthesized and evaluated for &#945;-glucosidase inhibitory potential. All synthesized analogs exhibited excellent inhibitory potential, with IC<sub>50</sub> values ran...

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Bibliographic Details
Main Authors: Muhammad Taha, Foziah J. Alshamrani, Fazal Rahim, Shawkat Hayat, Hayat Ullah, Khalid Zaman, Syahrul Imran, Khalid Mohammed Khan, Farzana Naz
Format: Article
Language:English
Published: MDPI AG 2019-10-01
Series:Molecules
Subjects:
synthesis
triazinoindole
thiosemicarbazide
alpha-glucosidase
molecular docking study
sar
Online Access:https://www.mdpi.com/1420-3049/24/21/3819

Internet

https://www.mdpi.com/1420-3049/24/21/3819

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